Synthesis of imidazole phosphinic acids as I4AA analogues |
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| Authors: | David Orain Henri Mattes |
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| Affiliation: | Global Discovery Chemistry-Neuroscience, Novartis Institute for Biomedical Research Basel, CH-4002 Basel, Switzerland |
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| Abstract: | The GABAC receptor has been identified as a potentially attractive target involved in a number of eye diseases. TPMPA is the best antagonist reported so far. The synthesis of two new pharmacophores based on imidazole phosphinic acid core structure will be presented. |
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| Keywords: | Phosphinic acid Imidazole GABA TPMPA |
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