Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative |
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| Authors: | Takahisa Ogamino |
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| Institution: | Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan |
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| Abstract: | Successful first synthesis of optically pure (+)- and (−)-aerothionins (1) from the racemic spiroisoxazoline derivative 8 has been accomplished. The absolute configuration of natural (+)-1 was determined by comparison of (+)- and (−)-8 with related derivatives. |
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| Keywords: | Spiroisoxazoline Bromotyrosine Diastereomeric separation Aerothionin |
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