A preliminary evaluation of a metathesis approach to bryostatins |
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Authors: | Matthew Ball |
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Institution: | The School of Chemistry, The University of Manchester, Manchester M13 9PL, UK |
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Abstract: | Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at C-18, did not undergo the required ring-closing metathesis. |
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