Synthesis of the constrained glutamate analogues (2S,1′R,2′R)- and (2S,1′S,2′S)-2-(2′-carboxycyclobutyl)glycines L-CBG-II and L-CBG-I by enzymatic transamination |
| |
Authors: | Xin Gu Thierry Gefflaut |
| |
Institution: | Laboratoire SEESIB-CNRS (UMR 6504), Département de Chimie, Université Blaise Pascal—Clermont-Ferrand II, 24, Avenue des Landais, 63177 Aubière cedex, France |
| |
Abstract: | Optically pure trans-cyclobutane analogues of glutamic acid are prepared by highly selective enzymatic transamination of a single racemic trans-cyclobutane α-ketoglutaric acid derivative 5, which is synthesized in five steps from maleic anhydride. (2S,1′R,2′R)- and (2S,1′S,2′S)-2-(2′-carboxycyclobutyl)glycines L-CBG-II and L-CBG-I are obtained using aspartate aminotransferase (AAT) and branched chain aminotransferase (BCAT), respectively. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|