Dicationic (BINAP)palladium-catalyzed enantioselective aldol reaction of aldehydes with a silyl enol ether: a simplified practical procedure |
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| Authors: | Syun-ichi Kiyooka Satomi Hosokawa Sayaka Tsukasa |
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| Institution: | Department of Materials Science, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan |
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| Abstract: | The dicationic ((R)-BINAP)palladium-catalyzed enantioselective aldol reaction of benzaldehyde with 1-phenyl-1-trimethylsilylethene has been reinvestigated regarding the reaction conditions in the presence of ((R)-BINAP)palladium chloride and AgSbF6 with 3 Å molecular sieves. The simplified practical procedure with 1 mol % catalyst loading realized the high performance of 98% yield and 76% ee with reliable reproducibility. |
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| Keywords: | Enantioselective aldol reaction Palladium-catalyzed aldol reaction Palladium enolate |
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