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A new and versatile one-pot synthesis of indol-2-ones by a novel Ugi-four-component-Heck reaction |
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| Authors: | Michael Umkehrer Cédric Kalinski Jürgen Kolb Christoph Burdack |
| Institution: | Priaton GmbH, Bahnhofstr. 9-15, D-82327 Tutzing, Germany |
| Abstract: | A novel one-pot-synthesis of highly substituted indol-2-ones using a combination of Ugi and Heck reaction (U-4CR-Heck) is described. The synthesized indol-2-ones represent an interesting pharmacological scaffold with four potential points of diversity. Thus, this novel reaction-type is amenable to combinatorial high-throughput screening. |
| Keywords: | Ugi reaction Heck reaction One-pot synthesis Indol-2-ones Multicomponent reaction Combinatorial chemistry |
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