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Synthesis of combretastatins A-1 and B-1 |
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| Authors: | Kristin Odlo |
| Affiliation: | School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway |
| Abstract: | Combretastatins A-1 and B-1 have been synthesized by coupling MOM-protected p-iodomethoxycatechol with 3,4,5-trimethoxyphenylacetylene in a Sonogashira reaction. |
| Keywords: | Combretastatins Tubulin inhibitors Sonogashira reaction |
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