Reaction of N-fluoropyridinium fluoride with isonitriles and diazo compounds: a one-pot synthesis of (pyridin-2-yl)-1H-1,2,3-triazoles |
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Authors: | Alexander S Kiselyov |
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Institution: | Small Molecule Drug Discovery, Chemical Diversity, 11558 Sorrento Valley Road, San Diego, CA 92121, USA |
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Abstract: | Reaction of N-fluoropyridinium fluoride generated in situ with a series of isonitriles and diazo compounds led to the formation of the corresponding (pyridine-2-yl)-1H-1,2,3-triazoles in good yields (37-59%). Best outcome was consistently achieved with both aromatic isonitriles and stabilized diazo derivatives. The proposed reaction mechanism involves the intermediate formation of a highly reactive carbene species. |
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Keywords: | N-Fluoropyridinium (Pyridine-2-yl)-1H-1 2 3-triazoles Isonitriles Carbene Three-component reaction |
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