Facile synthesis of α,α′ disubstituted N-hydroxypyrrolidines and N-hydroxypiperidines via double 1,4-addition of hydroxylamine |
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Authors: | Fré dé ric C. Bargiggia |
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Affiliation: | Johnson & Johnson Pharmaceutical Research and Development L.L.C., 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA |
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Abstract: | A versatile synthesis of α and α′ disubstituted N-hydroxypiperidine and N-hydroxypyrrolidine by consecutive double 1,4-addition of hydroxylamine on the corresponding bis α,β-unsaturated diester is described. This reaction takes place an environmentally friendly (ethanol/water) system and at room temperature. |
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