Efficient preparation of chiral diamines via Red-Al reduction of N-Boc-protected amino acid-derived secondary amides |
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| Authors: | Eric A Voight Matthew S Bodenstein Norihiro Ikemoto Michael H Kress |
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| Institution: | Merck Research Laboratories, Department of Process Research, Merck & Co., 466 Devon Park Drive, Wayne, PA 19087, USA |
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| Abstract: | Conditions have been developed for the selective reduction of N-Boc-protected amino acid-derived secondary amides, avoiding the formation of overreduction and cyclic urea byproducts. The method is showcased by the efficient formal synthesis of NK-1 antagonist LY303870. |
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