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Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium |
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| Authors: | T. Luke Simmons Kerry L. McPhail Susan L. Mooberry |
| Affiliation: | a Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0212, USA b College of Pharmacy, Oregon State University, Corvallis, OR 97331-4003, USA c Instituto de Investigaciones Científicas Avanzados y Sevicios de Alta Tecnología, Centro de Estudios Biomédicos, Clayton, Bldg. 175, PO Box 7250, Panama 5, Panama d Southwest Center for Biomedical Research, San Antonio, TX 78245, USA |
| Abstract: | The isolation and structure elucidation of belamide A from the marine cyanobacterium Symploca sp. is described. Belamide A is a highly methylated linear tetrapeptide with structural analogy to the important linear peptides dolastatins 10 and 15. Disruption of the microtubule network in A-10 cells was observed at 20 μM and displayed classic tubulin destabilizing antimitotic characteristics. The moderate cytotoxicity of belamide A (IC50 0.74 μM vs HCT-116 colon cancer line) provides new insights into structure-activity relationships for this drug class. |
| Keywords: | Symploca sp. Linear peptide Dolastatins Marine natural products |
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