Catalytic and stereoselective glycosylation with glycosyl N-trichloroacetylcarbamate |
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Authors: | Jun-ichi Matsuo |
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Institution: | Center for Basic Research, The Kitasato Institute, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8642, Japan |
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Abstract: | Catalytic and stereoselective glycosylation efficiently proceeded by activating a glycosyl N-trichloroacetylcarbamate with a catalytic amount of Lewis acids in the presence of a glycosyl acceptor and molecular sieves 5 Å. Catalytic and one-pot dehydrative glycosylation of a 1-hydroxy carbohydrate was also performed stereoselectively by the reaction with trichloroacetyl isocyanate followed by activation with a catalytic amount of activators. |
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Keywords: | Glycosylation Lewis acids Solvent effects Synthetic methods |
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