New, diastereoselective synthesis of 1-alkyl-5-alkylidene-3-methylidenepyrrolidin-2-ones |
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Authors: | Anna Albrecht |
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Affiliation: | Institute of Organic Chemistry, Technical University of ?ód?, ?eromskiego 116, 90-924 ?ód?, Poland |
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Abstract: | The diastereoselective synthesis of 1-alkyl-5-alkylidene-3-methylidenepyrrolidin-2-ones was readily accomplished in a two-step reaction sequence consisting of the reaction of 2-diethoxyphosphoryl-4-oxoalkanoates with amines followed by Horner-Wadsworth-Emmons olefination of formaldehyde using the intermediate 1-alkyl-5-alkylidene-3-diethoxyphosphorylpyrrolidin-2-ones. |
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Keywords: | Pyrrolidinones Horner-Wadsworth-Emmons olefination α-Methylidene-γ-lactams |
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