Di-μ-hydroxy-bis(N,N,N′,N′-tetramethylenediamine)-copper(II) chloride [Cu(OH)·TMEDA]2Cl2: an efficient, practical catalyst for benzylation and allylation of amides |
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| Authors: | G Kumaraswamy A Pitchaiah G Ramakrishna DS Ramakrishna K Sadaiah |
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| Institution: | Organic Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | An efficient protocol for the benzylation or allylation of amides using the corresponding benzyl or allyl chlorides as electrophiles under basic conditions with commercially available 5 mol % of Cu(OH)TMEDA]2Cl2 as catalyst was developed. Under these conditions, unprotected amino acids were benzylated without any racemization. |
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| Keywords: | Amidation Benzylation Allylation Copper salts [Cu(OH)TMEDA]2Cl2 |
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