Application of the intramolecular aza-Wittig reaction to the synthesis of pyrido[2,3-d]pyrimidines |
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Authors: | Johann Chan Margaret Faul |
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Institution: | Chemistry Process Research and Development, Amgen Inc., One Amgen Center Dr., Thousand Oaks, CA 91320, USA |
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Abstract: | Pyrido2,3-d]pyrimidines are synthesized in a two-step procedure from amides and tetrazolo1,5-a]pyridine-8-carbonyl chloride. Reaction of the crude imides with triphenylphosphine effects an intramolecular aza-Wittig reaction to afford a variety of substituted pyrido2,3-d]pyrimidines in good to moderate yields (30-76%). |
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Keywords: | Tetrazolo[1 5-a]pyridine-8-carbonyl chloride aza-Wittig Pyrido[2 3-d]pyrimidines Iminophosphoranes |
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