A new strategy for the regio- and stereoselective hydroxylation of trans-2-aminocyclohexenecarboxylic acid |
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| Authors: | Loránd Kiss |
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| Institution: | Institute of Pharmaceutical Chemistry, University of Szeged, PO Box 427, H-6701 Szeged, Hungary |
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| Abstract: | A simple and novel method for the introduction of an extra hydroxy group into an aminocyclohexanecarboxylic acid via stereoselective epoxidation and regioselective opening of the oxirane ring is presented. This method permits the preparation of the enantiomerically pure hydroxylated amino acid. |
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| Keywords: | Cyclic β-amino acids Epoxidation Hydroxylated amino acids Selective synthesis Enzymatic resolution |
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