Indium(I) iodide as a radical initiator: intramolecular cyclization of functionalized bromo-alkynes to substituted tetrahydrofurans |
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| Authors: | Brindaban C. Ranu Tanmay Mandal |
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| Affiliation: | Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India |
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| Abstract: | Aryl substituted α-carbonyl bromo-alkynes undergo facile cyclizations to the corresponding substituted 4-methylene-tetrahydrofurans using indium(I) iodide in acetonitrile under sonication in high yields. The reaction is predicted to proceed via a radical process initiated by InI and a plausible radical pathway is suggested. |
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| Keywords: | Indium(I) iodide Radical Bromo-alkyne Tetrahydrofuran Ultrasound |
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