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Formal synthesis of (±)-perhydrohistrionicotoxin via a stepwise [3+3] annelation strategy |
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| Authors: | Olivier Y Provoost Andrew J Hazelwood |
| Institution: | a Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, UK b GlaxoSmith Kline Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK |
| Abstract: | A formal synthesis of (±)-perhydrohistrionicotoxin is described that includes a highly diastereoselective modified Sharpless aziridination and a stepwise 3+3] annelation reaction for the stereoselective construction of the key spiropiperidine motif. |
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