Simple method for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine for photoaffinity labeling |
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| Authors: | Makoto Hashimoto Yuhi Kato |
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| Affiliation: | a Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro 080-8555, Hokkaido, Japan
b Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2360 Sugitani, Toyama 930-0194, Japan |
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| Abstract: | A simple and mild method was developed for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine (TPD) aromatic ring in the presence of three membered diazirine ring. An iodination protocol, I2-BTI in CH3CN, was found to be effective even though affinity ligands are pre-installed. |
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