Novel route to the synthesis of 4-quinolyl isothiocyanates |
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| Authors: | Boyu Zhong Rima S Al-Awar Chuan Shih John H Grimes Jr Michal Vieth Chafiq Hamdouchi |
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| Institution: | Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA |
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| Abstract: | 4-Quinolyl isothiocyanates were synthesized in a regiospecific fashion from the corresponding 4-chloroquinolines and silver thiocyanate in refluxing toluene. The products were isolated in quantitative yield and high purity (>95%) by simple filtration and concentration. Reactivity and mechanism of the reaction are discussed. The new approach would provide a new mean which had been lacking for the synthesis of functionalized 4-quinolinyl isothiocyanate. |
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| Keywords: | 4-Quinolyl isothiocyanate Thiocyanate Silver thiocyanate |
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