Synthesis of novel indole based cyclophanes and cylindrical cyclophanes by tandem alkylation methodology using NaH |
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| Authors: | Perumal Rajakumar Merikapudi Gayatri Swaroop |
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| Institution: | Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India |
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| Abstract: | Treatment of 1 equiv of 1,3-bis(bromomethyl)benzene and 2,6-bis(bromomethyl)pyridine with 1 equiv of indole in the presence of NaH in THF afforded the symmetrical cyclophanes 1 and 2. Using similar methodology, cylindrical cyclophanes 3 and 4 were obtained from 2 equiv of 1,3,5-trimethyl-2,4,6-tris(bromomethyl)benzene and 1,3,5-tris(bromomethyl)benzene with 3 equiv of indole. |
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