Palladium-catalyzed cross-coupling of 2-haloselenophene with terminal alkynes in the absence of additive |
| |
Authors: | Olga Soares do Rêgo Barros Cristina W Nogueira Gilson Zeni |
| |
Institution: | a Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios, CCNE, UFSM, Santa Maria, Rio Grande do Sul CEP 97105-900, Brazil b Departamento de Química Fundamental, UFPE, Recife, PE 50670-901, Brazil |
| |
Abstract: | We present herein our results of the Sonogashira coupling reaction of 2-haloselenophenes with terminal alkynes catalyzed by PdCl2(PPh3)2, under co-catalyst free conditions and establish a new procedure to prepare (2-alkynyl)-selenophenes in good yields. The reaction proceeded cleanly under mild reaction conditions and was performed with propargylic alcohols, protected propargylic alcohols, propargylic amines, as well as alkyl, and aryl alkynes, in the presence of PdCl2(PPh3)2, Et3N, DMF, and in the absence of any supplementary additives. In addition, by this protocol (2,5-bis-alkynyl)-selenophenes were also obtained, in a one pot procedure, using 2,5-bis-iodoselenofene with an excess of terminal alkynes. |
| |
Keywords: | Selenides Palladium cross-coupling Selenophene |
本文献已被 ScienceDirect 等数据库收录! |
|