An efficient conversion of nitriles to amides: application in the synthesis of N,N-diethyl-m-toluamide (DEET™) |
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| Authors: | Apurba Bhattacharya Robert Erik Plata Savitha Muramulla |
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| Affiliation: | a Department of Chemistry, Texas A&M University-Kingsville, Kingsville, TX 78363, USA
b J&J Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA |
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| Abstract: | Arylnitriles react with magnesium amides to produce carboxamides in excellent yield. The method was applied for the preparation of the insect repellent DEET™. |
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