a George Barasch Bioorganic Research Laboratory, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA b Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA
Abstract:
Highly accelerated and safe nitration of phenolic compounds has been found to be feasible with a mixture of calcium nitrate and acetic acid as an efficient nitration agent under brief microwave irradiation. This method is compatible with the green chemistry approach because calcium salts—the inorganic byproducts—can be useful agrochemicals rather than waste chemicals. Commercially available 15N-labeled calcium nitrate is convenient for the preparation of 15N-labeled compounds for metabolic studies and mass spectrometry. This safe nitration method can be included in laboratory experiments for high school and college students.