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Highly enantioselective reduction of ketones by chiral diol-modified lithium aluminum hydride reagents |
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| Authors: | Yunlai Ren Xinzhe Tian Jian Xu Xianlun Xu Shijie Lu |
| Affiliation: | a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 342 Tianshui Road, Lanzhou 730000, China b Graduate School of Chinese Academy of Sciences, Beijing 100039, China c School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China |
| Abstract: | Some readily available chiral diols from indene and d-mannitol were investigated as chiral modifiers in lithium aluminum hydride reduction of ketones, and it was discovered that further modification of these reducing reagents by a simple a-amino alcohol resulted in a remarkable increase in optical yield. Among the investigated chiral modifiers, chiral diol 1 gave the highest enantioselectivities. |
| Keywords: | Asymmetric reduction Ketone Diol Lithium tetrahydridoaluminate |
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