Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins |
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| Authors: | Jeffrey Walton Simon J Webb |
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| Institution: | a Manchester Interdisciplinary Biocentre, School of Chemistry, University of Manchester, Oxford Rd, Manchester M13 9PL, UK
b Molecular Materials Centre, School of Chemical Engineering and Analytical Science, University of Manchester, Sackville St, PO Box 88, Manchester M60 1QD, UK |
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| Abstract: | A series of new sugar-based nonionic surfactants have been synthesized and their lyotropic liquid crystalline properties characterized. When in contact with water, these surfactants formed a range of lyotropic liquid crystalline phases, including cubic, hexagonal, and lamellar, as well as a separate micellar phase. These are features that have promise for the crystallization of integral membrane proteins. |
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