Solvent-free microwave synthesis of 4-hydroxy-3-phenylquinolin-2(1H)-ones and variants using activated arylmalonates |
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| Authors: | Alexey Rivkin Bruce Adams |
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| Affiliation: | Merck Research Laboratories, Department of Chemistry, 33 Avenue Louis Pasteur, Boston, MA 02115, USA |
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| Abstract: | The disclosure herein describes the rapid synthesis of 4-hydroxy-3-phenylquinolin-2(1H)-ones and variants via a solvent-free microwave cyclocondensation reaction using di-(2,4,6-trichlorophenyl)-2-phenylmalonate, which improves the general scope of this reaction. |
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| Keywords: | Microwave reaction 4-Hydroxyquinolin-2(1H)-ones 4-Hydroxy-2(1H)-pyridones Di-(2,4,6-trichlorophenyl)-2-phenylmalonate Pharmaceutical agents |
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