Mitsunobu reactions of nucleoside analogs using triisopropyl phosphite-DIAD |
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| Authors: | Eduardo A Véliz |
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| Institution: | Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, USA |
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| Abstract: | Herein, we report the use of triisopropyl phosphite (TIP) as an effective substitute for triphenylphosphine in the Mitsunobu reaction of nucleoside analogs. In addition, the use of triphenyl phosphite as an alternative reagent for the expensive hexamethylphosphorous triamide (HMPT) in the Véliz-Beal bromination protocol is reported. |
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| Keywords: | Nucleoside analogs Mitsunobu reaction Phosphites |
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