Stereoselective synthesis of trans-2,3-disubstituted pyrrolidines via addition to N-acyliminium ions |
| |
| Authors: | Nuria Diaz Buezo Paloma Vidal |
| |
| Affiliation: | Departamento de Investigación Lilly S.A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain |
| |
| Abstract: | An efficient and stereoselective synthesis of trans-2,3-disubstituted pyrrolidines is described. The intermolecular alkylation of racemic N-acyliminium ions generated in situ from the corresponding 3-substituted lactams proceeds stereoselectively and in high yield. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
