Stereoselective synthesis of trans-2,3-disubstituted pyrrolidines via addition to N-acyliminium ions |
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| Authors: | Nuria Diaz Buezo Paloma Vidal |
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| Institution: | Departamento de Investigación Lilly S.A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain |
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| Abstract: | An efficient and stereoselective synthesis of trans-2,3-disubstituted pyrrolidines is described. The intermolecular alkylation of racemic N-acyliminium ions generated in situ from the corresponding 3-substituted lactams proceeds stereoselectively and in high yield. |
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