|
|||||
|
|
High throughput evaluation of the production of substituted acetylenes by the Sonogashira reaction followed by the Mizoroki-Heck reaction in ionic liquids, in situ, using a novel array reactor |
|
| Authors: | Md. Taifur Rahman Ilhyong Ryu Koichi Yonemura Kiyoshi Nokihara |
| Affiliation: | a Department of Chemistry, Faculty of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan b HiPep Laboratories, 486-46 Nakatsukasa-cho, Kamigyo-ku, Kyoto 602-8158, Japan c InnovaSyn, LLC, 627 Arlington St. Chapel Hill, NC 27514, USA d Nanjing Medical University, 300 Kanshu Ro Nanjing 210029, China |
| Abstract: | The parallel Sonogashira coupling reaction was carried out under copper-free condition by integrating the advantages of ionic liquids as the reaction media followed by the simultaneous-multiple Mizoroki-Heck reaction in situ by the use of a novel array reactor (SynArray-24). The device provides rapid evaluation of reactions in a short period. |
| Keywords: | Array reactor Combinatorial solution synthesis Sonogashira reaction Mizoroki-Heck reaction |
| 本文献已被 ScienceDirect 等数据库收录！ | |