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Efficient synthesis of functionalized pyrimidones via microwave-accelerated rearrangement reaction |
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| Authors: | Yong-Li Zhong Hua Zhou Donald R Gauthier Jr David Askin |
| Institution: | Department of Process Research, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA |
| Abstract: | An efficient synthesis of functionalized pyrimidones via microwave-accelerated rearrangement reaction of amidoxime DMAD adducts is described. In most cases, the pyrimidone formation was furnished in reasonable yield after 2 min of microwave irradiation. |
| Keywords: | Pyrimidone Hydroxyamidine Rearrangement Heterocyclic compounds Microwave irradiation |
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