Ileabethoxazole: a novel benzoxazole alkaloid with antimycobacterial activity |
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| Authors: | Ileana I. Rodrí guez,Yuehong Wang |
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| Affiliation: | a Department of Chemistry, University of Puerto Rico, PO Box 23346, U.P.R. Station, San Juan 00931-3346, PR, USA
b Institute for Tuberculosis Research, College of Pharmacy, The University of Illinois at Chicago, Chicago, IL 60612-7231, USA |
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| Abstract: | Ileabethoxazole (1), a new perhydroacenaphthene-type diterpene alkaloid containing the uncommon benzoxazole moiety, was isolated from the Caribbean sea whip Pseudopterogorgia elisabethae. The structure of 1 was elucidated by extensive spectroscopic data interpretation. Ileabethoxazole showed 92% inhibition of Mycobacterium tuberculosis (H37Rv) at the concentration range of 128-64 μg/mL. |
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| Keywords: | Pseudopterogorgia elisabethae Tuberculosis Caribbean gorgonian octocorals Ileabethane skeleton Benzoxazole Mycobacterium |
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