A highly efficient synthesis of 22-deoxy-OSW-1 by utilizing the intact skeleton of diosgenin |
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| Authors: | Hong-Jian Qin Wei-Sheng Tian Cui-Wu Lin |
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| Institution: | a Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
b School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China |
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| Abstract: | 22-Deoxy-OSW-1 (1), an analogue of OSW-1 with the potent anticancer activity, was synthesized by utilizing the intact skeleton of diosgenin in 11 steps in 13.7% overall yield. This synthesis demonstrated an effective and reasonable synthetic strategy for bioactive steroids with side chains. |
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