ZrCl4 dispersed on dry silica gel provides a useful reagent for S-alkylation of thiols with alcohols under solvent-free conditions

ZrCl₄ which is commercially available and not a costly compound, is a relatively safe chemical [LD₅₀ [ZrCl₄, oral rat] = 1688 mg Kg]. In this report we describe the use of ZrCl₄ dispersed on dry silica gel as an efficient reagent for the efficient preparation of thioethers from thiols with alcohols under solvent-free conditions.