A general route to the Streptomyces-derived inthomycin family: the first synthesis of (+)-inthomycin B |
| |
| Authors: | Michael R Webb Richard JK Taylor |
| |
| Institution: | a Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
b AstraZeneca, Alderley Park, Macclesfield SK10 5DD, UK |
| |
| Abstract: | A concise, convergent and stereocontrolled synthesis of (+)-inthomycin B, based on the Stille coupling of a stannyl-diene with an oxazole vinyl iodide unit, is described. The asymmetric centre was introduced using the Kiyooka ketene acetal/amino acid-derived oxazaborolidinone procedure. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
