A simple and efficient one step synthesis of 1,3,4-oxadiazoles utilizing polymer-supported reagents and microwave heating |
| |
| Authors: | Ying Wang Daryl R Sauer Stevan W Djuric |
| |
| Institution: | High-Throughput Organic Synthesis Group, Medicinal Chemistry Technologies, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6113, USA |
| |
| Abstract: | 1,3,4-Oxadiazoles can be rapidly and efficiently synthesized from a variety of carboxylic acids and acid hydrazides in one simple step. The use of commercially available PS-PPh3 resin combined with microwave heating delivered the product 1,3,4-oxadiazoles in high yields and purities. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
