Use of functionalized aromatic organozinc reagents in the three-component Mannich-type synthesis of diarylmethylamines |
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| Authors: | Erwan Le Gall Michel Troupel Jean-Yves Nédélec |
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| Institution: | Laboratoire d’Electrochimie, Catalyse et Synthèse Organique, LECSO, CNRS-Université Paris 12 Val de Marne, UMR 7582, 2-8 rue Henri Dunant, 94320 Thiais, France |
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| Abstract: | Efficient syntheses of functionalized diarylmethylamines have been realized according to a one-step three-component coupling between an aromatic aldehyde, a secondary amine and an aromatic organozinc reagent. Phenyl rings can be substituted by functional groups and either aromatic or non-aromatic amines can be used in this process. |
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| Keywords: | Diarylmethylamines Three-component reaction Aromatic organozinc reagents Aromatic aldehydes Secondary amines |
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