Sulfated zirconia, a mild alternative to mineral acids in the synthesis of hydroxycoumarins |
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| Authors: | Juan Carlos Rodríguez-Domínguez Gilbert Kirsch |
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| Institution: | a Departamento de Química, Centro de Química Farmacéutica, Calle 200 y 21, Atabey, Playa, CP. 11600, Ciudad de la Habana, Cuba
b Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique (LIMBP), Université de Metz, 1, Boulevard Arago, 57078 Metz, France |
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| Abstract: | Sulfated zirconia (1%) was employed as Pechmann’s catalyst without solvent or in some cases using a small amount of ethanol to obtain coumarins in moderate to good yields. With this procedure, no significant acidic waste was obtained and an environmental friendly alternative to obtain coumarins is provided. |
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| Keywords: | Coumarins Pechmann&rsquo s reaction |
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