Total synthesis of bioactive frustulosin and frustulosinol |
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| Authors: | Mary-Lorè ne Goddard |
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| Affiliation: | Institut de Chimie de l’Université de Neuchatel, Avenue de Bellevaux 51, CH-2000 Neuchatel, Switzerland |
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| Abstract: | Stereum hirsutum is a pathogenic fungus involved in ‘Esca’, a trunk wood disease of grapevine. Among the metabolites isolated from the culture medium of this fungus, frustulosin (2a) shows a high phytotoxicity. A new simple and efficient method for the synthesis of frustulosin (2a) and frustulosinol (2b) was developed. Antibacterial activity and phytotoxicity are reported. |
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