| 2-取代的6-溴甲基-4(3H)-喹唑啉酮的合成 |
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| 引用本文： | 曹胜利,冯玉萍,高红核,冯克然. 2-取代的6-溴甲基-4(3H)-喹唑啉酮的合成[J]. 应用化学, 2005, 22(9): 1027-1029 |
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| 作者姓名： | 曹胜利 冯玉萍 高红核 冯克然 |
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| 作者单位： | a首都师范大学，清华大学 |
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| 基金项目： | 北京市自然科学基金资助项目(7002006,7042006)，教育部科学技术研究重点项目(2002KJ091) |
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| 摘 要： | 2-取代的6-溴甲基-4(3H)-喹唑啉酮的合成;4(3H)-喹唑啉酮;苯并噁嗪酮;N-溴代琥珀酰亚胺; 合成
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| 关 键 词： | 2-取代的6-溴甲基-4(3H)-喹唑啉酮的合成 4(3H)-喹唑啉酮 苯并噁嗪酮 N-溴代琥珀酰亚胺 合成 |
| 文章编号： | 1000-0518(2005)09-1027-03 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2004-11-06 |
Syntheses of 2-Substituted 6-Bromomethyl-4 (3H) -Quinazolinones |
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| CAO Sheng-Li,FENG Yu-Ping,GAO Hong-He,FENG Ke-Ran. Syntheses of 2-Substituted 6-Bromomethyl-4 (3H) -Quinazolinones[J]. Chinese Journal of Applied Chemistry, 2005, 22(9): 1027-1029 |
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| Authors: | CAO Sheng-Li FENG Yu-Ping GAO Hong-He FENG Ke-Ran |
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| Affiliation: | CAO Sheng-Li~ |
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| Abstract: | 2-Amino-5-methylbenzoic acid(1) was acylated with acyl chlorides,then heated(together) with(acetic) anhydride to give 2-phenyl or 2-benzyl-6-methylbenzoxazin-4-one(3a~3b),while compound 1 was (reacted) with propanoic anhydride or trifluoroacetic anhydride to give 2-ethyl or 2-trifluoromethyl-6-methylbenzoxazin-4-one(3c~3d) directly. Then,2-substituted 6-methylbenzoxazin-4-ones(3a~3d) were heated together with formamide to afford 2-substituted 6-methyl-4(3H)-quinazolinones(4a~4d),which were(converted) into the title compounds(5a~5d) via brominating with N-bromosuccinimide in the presence of (PhCOO)_(2).The structures of all the intermediates and final products were confirmed with ESI-MS,~(1)H NMR and elemental analysis. |
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| Keywords: | 4(3H)-quinazolinone benzoxazinone N-bromosuccinimide synthesis |
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