Palladium- and nickel-catalyzed intramolecular cyanoboration of alkynes |
| |
Authors: | Suginome Michinori Yamamoto Akihiko Murakami Masahiro |
| |
Affiliation: | Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, and PRESTO, Japan Science and Technology Corporation (JST), Sakyo-ku, Kyoto 606-8501, Japan. suginome@sbchem.kyoto-u.ac.jp |
| |
Abstract: | Intramolecular addition of a boron-cyano bond across a carbon-carbon triple bond was achieved using palladium and nickel catalysts. Cyano(diisopropylamino)boryl homopropargyl ethers underwent regio- and stereoselective 5-exo cyclization, forming five-membered cyclic boryl ethers in high yields. The cyanoboration products thus obtained served as new precursors for the synthesis of highly substituted alpha,beta-unsaturated nitriles via transition-metal-catalyzed transformations. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|