Synthesis and antimicrobial activity of Schiff bases and 2-azetidinones derived from quinazolin-4(3H)-one |
| |
Authors: | Navin B Patel Jaymin C Patel |
| |
Institution: | Department of Chemistry, Organic Research Laboratory, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India |
| |
Abstract: | A series of 2-oxo-azetidinyl-quinazolin-4(3H)-ones 5a–k have been synthesized from Schiff bases 4a–k. Schiff bases were synthesized by the condensation reaction of compound 3 with substituted aromatic aldehydes. The benzoxazinone 2 was prepared by the cyclization reaction of acid chloride 1 with 5-bromo anthranilic acid. Further reaction of benzoxazinone 2 with hydrazine hydrate yielded compound 3. The structures of the synthesized compounds were elucidated on the basis of elemental analyses as well as IR and NMR spectral data. Schiff bases 4a–k and 2-azetidinones 5a–k were screened for antibacterial and antifungal activities in vitro. Compounds having chloro and methoxy groups exhibited good antimicrobial activity. |
| |
Keywords: | Antimicrobial activity 2-Azetidinone Quinazolinone Schiff base |
本文献已被 ScienceDirect 等数据库收录! |