Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages |
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Authors: | Roberto Fernández-Maestre Herbert H Hill Jr |
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Institution: | (1) Department of Chemistry, Washington State University, Pullman, WA 99163, USA;(2) Present address: Programa de Quimica, Campus de Zaragocilla, Universidad de Cartagena, Cartagena, Colombia |
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Abstract: | In the pharmaceutical industry, there are increasing requirements for analytical methods in quality assessment for the production
of drugs. In this investigation, ion mobility spectrometry (IMS) was used for the rapid qualitative separation and identification
of active ingredients in generic over-the-counter drugs and food additives in beverages. The active ingredients determined
in drugs were acetaminophen, aspartame, bisacodyl, caffeine, dextromethorphan, diphenhydramine, famotidine, glucosamine, guaifenesin,
loratadine, niacin, phenylephrine, pyridoxine, thiamin, and tetrahydrozoline. Aspartame and caffeine were determined in beverages.
Fourteen over-the-counter drugs and beverages were analyzed. Analysis times below 10 s were obtained for IMS, and reduced
mobilities were reported for the first time for 12 compounds. A quadrupole mass spectrometer coupled to a mobility spectrometer
was used to assure a correct peak assignation. The combination of fast analysis, low cost, and inexpensive maintenance of
IMS instruments makes IMS an attractive technique for the qualitative determination of the active ingredients in over-the-counter
drugs and food additives in manufacture quality control and cleaning verification for the drug and food industries. |
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Keywords: | Ion mobility spectrometry Over-the-counter drug Food additive Sweetener |
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