| 壳聚糖及其疏水衍生物自缔合行为 |
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| 引用本文： | 孙书军,刘文广,姚康德.壳聚糖及其疏水衍生物自缔合行为[J].化学进展,2004,16(6):984-988. |
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| 作者姓名： | 孙书军 刘文广 姚康德 |
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| 作者单位： | 天津大学高分子材料研究所,天津,300072;天津大学高分子材料研究所,天津,300072;天津大学高分子材料研究所,天津,300072 |
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| 基金项目： | 国家自然科学基金重点项目资助 (No .5 0 2 330 2 0 ) |
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| 摘 要： | 过去几十年里,有关疏水改性聚电解质的理论和应用研究取得了长足的进展,通常认为其不同寻常的流变及溶解特性是由疏水基团的分子间或分子内相互作用产生的.本文综述了近年来有关壳聚糖及脱氧胆酸、烷基化和棕榈酰改性壳聚糖衍生物自缔合性质的研究进展,并简要介绍它们在药物释放和转基因领域的应用研究.
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| 关 键 词： | 壳聚糖 疏水性 自缔合 释放 |
| 文章编号： | 1005-281X(2004)06-0984-05 |
| 收稿时间： | 2003-10-01 |
| 修稿时间： | 2003年10月1日 |
The Self-Association Behavior of Chitosan and Its Hydrophobic Derivatives |
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| Sun Shujun,Liu Wenguang,Yao Kangde.The Self-Association Behavior of Chitosan and Its Hydrophobic Derivatives[J].Progress in Chemistry,2004,16(6):984-988. |
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| Authors: | Sun Shujun Liu Wenguang Yao Kangde |
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| Institution: | （Research Institute of Polymeric Materials , Tianjin University， Tianjin 300072, China) |
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| Abstract: | Over the past decades, much progress has been made in the theoretical research and the application of hydrophobically-modified polyelectrolytes(HMPEs).The HMPEs show unusual rheological features and high solubilization properties, which are generally considered to originate from the inter-or intra interaction of hydrophobic moieties. In this article, the latest progress in the study on the self-association behaviors of chitosan, deoxycholic acid-, alkyl- and palmitoyl-modified chitosan derivatives is reviewed. Their applications in drug delivery system and transgenic vectors are described as well. |
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| Keywords: | chitosan hydrophobicity self-association delivery |
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