| 多甘醇-磷酸酯-EDTA酯共聚物铁(Ⅲ)配合物的合成和磁共振成象增强作用 |
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| 引用本文： | 俞开潮,冯继文.多甘醇-磷酸酯-EDTA酯共聚物铁(Ⅲ)配合物的合成和磁共振成象增强作用[J].波谱学杂志,1998,15(2):123-130. |
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| 作者姓名： | 俞开潮 冯继文 |
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| 作者单位： | 1.中国科学院武汉物理与数学研究所, 武汉 430071;2.武汉大学化学学院, 武汉 430072 |
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| 基金项目： | 波谱与原子分子物理国家重点实验室基金资助项目 |
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| 摘 要： | 通过乙二胺四乙酸双酸酐、二氯磷酸酯与多甘醇共缩聚,制得一系列三元共聚物配体.用配体与三氯化铁反应,得到相应的铁配合物.表征了配体和配合物的化学结构,测试了配合物的纵向弛豫速率,并考察了配合物的急性毒性和磁共振成象增强作用.
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| 关 键 词： | 磁共振成象 铁配合物 大分子造影剂 弛豫效能 急性毒性 |
| 收稿时间： | 1997-11-03 |
SYNTHESIS AND MRI ENHANCEMENT OF IRON(Ⅲ) COMPLEXES WITH PHOSPHATEEDTA-POLYGLYCOL TERPOLYMER LIGANDS |
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| Yu Kaichao,Feng Jiwen,Hu hongbing,Lu Guang,Zhuo Renxi,Li liyun,Ye Chaohui.SYNTHESIS AND MRI ENHANCEMENT OF IRON(Ⅲ) COMPLEXES WITH PHOSPHATEEDTA-POLYGLYCOL TERPOLYMER LIGANDS[J].Chinese Journal of Magnetic Resonance,1998,15(2):123-130. |
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| Authors: | Yu Kaichao Feng Jiwen Hu hongbing Lu Guang Zhuo Renxi Li liyun Ye Chaohui |
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| Institution: | 1.Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071;2.School of Chemistry, Wuhan University. Wuhan 430072 |
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| Abstract: | A new series of polyglycol-phosphate-EDTA ester terpolymer ligands were synthesized by the copoly merization of ethylene diamine tetraacetic dianhydride(EDTAA), ethyl phosphodichloridate (or methyl phosphodichloridate, n-butyl phosphodichloridate) with diethylene glycol or triethyleneglycol, and their Fe(Ⅲ) complexes were prepared. The structures of these new ligands and Fe (Ⅲ) complexes were comfirmed by 1H NMR, IR and elemental a nalysis. The longitudinal relaxation measurements on these macromolecular complexes indicated that most of them have higher relaxivity as compared to Fe(Ⅲ)-EDTA. Moreover, the acute toxicity test using one of these Fe (Ⅲ) complexes was performed and no obvious toxicity was observed. Finally, T1-weighted contrast imaging of rat liver showed clear MRI enhancement after injection the new complex. |
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| Keywords: | Magnetic resonance imaging Fe (Ⅲ) complex Macromolecular contrast agent Relaxivity Acute toxicity |
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