| First synthesis of (±)-cedarmycin B |
| |
| 作者姓名： | Hai Shen Yang Xiao Xiao Qiao Qing Cui Xiao Hua Xu |
| |
| 作者单位： | State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
| |
| 基金项目： | the National Science Foundation of China(Nos.20421202,20572055)for financial support |
| |
| 摘 要： | The synthesis of racemic cedarmycin B,an antibiotic from Streptomyces sp.TP-A0456 was achieved firstly fromγ- butyrolactone.The key step was a Barbier-type addition of 3-bromomethyl-5H-furan-2-one to formaldehyde mediated by zinc, which afforded the soleγ-addition product 4-hydroxymethyl-3-methylene-dihydrofuran-2-one.The final compound was confirmed by ~1H NMR,~(13)C NMR and HRMS.
|
| 收稿时间： | 2009-02-13 |
| 本文献已被 CNKI 万方数据 ScienceDirect 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
