Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae) |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor Bahru, Malaysia;2. Forest Research Institute Malaysia (FRIM), Kepong, 52109 Kuala Lumpur, Malaysia;3. Department of Pharmacy, Faculty of Science, Andalas University, Padang, Indonesia;4. Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12311, Egypt |
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| Abstract: | The crude extracts and isolated compounds of Piper porphyrophyllum (Piperaceae) were evaluated for antibacterial and anti-inflammatory activities. The ethyl acetate extract and 3′,4′,5,7-tetramethoxyflavone exhibited the highest activity against Staphylococcus aureus giving values of MIC = 62.5 and 250 μg/mL, respectively. 5-Hydroxy-7-methoxyflavanone and 4′,5-dihydroxy-3′,7-dimethoxyflavone were active against Pseudomonas aeruginosa, both with MIC value 125 μg/mL. The hexane extract and 4′,5-dihydroxy-3′,7-dimethoxyflavone gave the highest anti-inflammatory activity in in vitro quantitative lipoxygenase inhibition assay with inhibitory activity of (IE) 99.72% and 91.81%, respectively. |
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| Keywords: | Extracts Flavonoids Antibacterial Anti-inflammatory |
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