Synthesis,characterization and antimicrobial evaluation of 2,5-disubstituted-4-thiazolidinone derivatives |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, G.V.M. College of Pharmacy, Sonepat 131 001, India;2. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125 001, India;3. Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136 118, India;4. Department of Pharmaceutical Sciences, S.D. College of Pharmacy, Barnala 148 101, India;5. Department of Pharmaceutical Sciences, Hindu College of Pharmacy, Sonepat 131 001, India;6. Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozpur Road, Moga 142 001, India |
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| Abstract: | In the present study novel derivatives of 4-thiazolidinone were prepared from biphenyl-4-carboxylic acid and evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger. The newly synthesized compounds were characterized by IR, 1H NMR and C, H, N analyses. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Among the synthesized derivatives 4g (biphenyl-4-carboxylic acid [2-(3-bromophenyl)-5-(3-nitrobenzylidene)-4-oxo-thiazolidin-3-yl]-amide) and 4i (biphenyl-4-carboxylic acid [5-(3-bromobenzylidene)-2-(3-bromophenyl)-4-oxo-thiazolidin-3-yl]-amide) were found to be most effective antimicrobial compounds. |
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| Keywords: | Hydrazones 4-Thiazolidinone Antibacterial and antifungal activity |
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