环钯化二茂铁亚胺卡宾络合物的合成、表征及其对Buchwald-Hartwig胺化反应的催化性质

合成了一个新的二茂铁亚胺环钯化卡宾络合物, 并经过IR, 1H NMR, 13C NMR, HRMS和X射线衍射对其单晶结构进行鉴定. 新合成的催化剂对空气和湿气都很稳定, 并且对氯代苯参与的Buchwald-Hartwig胺化反应有较好的催化活性, 在摩尔分数为0.5%的催化剂用量下, 3 h即可以达到中等以上的收率.

Synthesis,Characterization and Catalytic Activity of Cyclopalladated Ferrocenylimine Carbene Complex in Buchwald-Hartwig Amination

The palladium-catalyzed amination of aryl halides(Buchwald-Hartwig amination) is a rapidly developing field due to the importance of the products in many fields, e.g. pharmaceuticals, xerography, electronic materials and ligands for transition metals. In this article, a novel cyclopalladated ferrocenylimine carbene complex 3 was conveniently synthesized and characterized via IR, 1H NMR, 13C NMR, HRMS and X-ray single crystal diffraction. Compound 3 was stable to air and moisture in both the solid state and solution. It was successfully applied for the Buchwald-Hartwig amination of aryl chlorides. Using 0.5%(molar fraction) of catalyst 3, in the presence of 2 equiv of tBuOK as a base in dioxane at 110 ℃ for 3 h, a variety of aryl chlorides and amines could be coupled to afford the coupled products in moderate or excellent yields.